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KMID : 0604220070140030081
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Korean Journal Investigative Dermatology
2007 Volume.14 No. 3 p.81 ~ p.86
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Effect of Red Ginseng Total Saponins on the Hair Follicles
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Cho Dae-Kyoung
Lee Jeung-Hoon
Kim Chang-Duk
Roh Seok-Sun
Hwang Chul
Lee Min-Ho
Rang Moon-Jeong
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Abstract
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Background: Red ginseng is one of the most popular medicinal plants in oriental medicine, and it has been well known that ginseng has a variety of activities against many diseases.
Purpose: In the present study, effect of red ginseng total saponins(RGTS) on the hair follicles was examined.
Methods: Human hair follicles and mouse vibrissa follicles were cultured organo-typically and the effect on the growth of hair follicles was measured using [35S]cysteine uptake method. The DNA synthesis in human hair dermal papilla cells was also investigated using [3H]thymidine incorporation assay. The effect on the expression level of insulin-like growth factor-1(IGF-1), keratinocyte growth factor(KGF), hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) in dermal papilla cells was measured by semi-quantitative RT-PCR.
Results: RGTS increased the [35S]cysteine uptake in both human scalp hair and mouse vibrissa follicles cultured in vitro. In addition, RGTS increased DNA synthesis in human hair dermal papilla cells cultured in vitro. However, RGTS had no effect on the gene expression of growth factors such as IGF-1, KGF, HGF and VEGF in dermal papilla cells.
Conclusion: These results suggest that RGTS may have impact on the hair growth.
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KEYWORD
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Red ginseng total saponins, Hair growth, Hair follicle organ culture, Dermal papilla cells
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